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DR56.1 DataRelease

Release Date: July 2025
New Studies: 13
Updated Studies: 16

New Studies

SDY3123: Immunogenicity and protective efficacy of an intranasal neuraminidase-based influenza virus vaccine adjuvanted with bacterial cell membrane-derived adjuvants
Status: New
Description: Here, the authors evaluated the local and systemic humoral and cellular immune responses to adjuvanted recombinant N1 NA.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/M3GKZBI89W
Subjects: 0
Study PI, contact:
NameOrganizationSite
Kirill Vasilev Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM-CIVIC)
Publications:
None. None None None. doi: None [Pubmed: Not Applicable]
Resources:
Not Applicable Not Applicable]
Assays:None
Clinical Assessments:None

SDY3128: Characterization of SARS-CoV-2 Spike mutations
Status: New
Description: Here we show that serial passaging of USA-WA1/2020 strain in mouse lungs results in mouse-adapted SARS-CoV-2 (MA-SARS-CoV-2) with mutations in S, M, and N genes, and a twelve-nucleotide insertion in the S gene.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/M301EUT53A
Subjects: 258
Study PI, contact:
NameOrganizationSite
Michael Schotsaert Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM-CIVIC)
Publications:
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.. Nature communications Jul 2022. doi: 10.1038/s41467-022-30763-0 [Pubmed: 35798721]
Resources:
Not Applicable Not Applicable]
Assays:
Assay TypeNumber of Exp. Samples
Q-PCR 75
Virus Neutralization 230
Virus Plaque Assay 112
Clinical Assessments:
Infection-Status_N1
Infection-Status_N2
Infection-Status_N3
Infection-Status_N4
Infection-Status_P1
Infection-Status_P10
Infection-Status_P11
Infection-Status_P12
Infection-Status_P13
Infection-Status_P14
Infection-Status_P15
Infection-Status_P16
Infection-Status_P17
Infection-Status_P18
Infection-Status_P19
Infection-Status_P2
Infection-Status_P20
Infection-Status_P21
Infection-Status_P22
Infection-Status_P23
Infection-Status_P24
Infection-Status_P25
Infection-Status_P26
Infection-Status_P27
Infection-Status_P28
Infection-Status_P29
Infection-Status_P3
Infection-Status_P30
Infection-Status_P4
Infection-Status_P5
Infection-Status_P6
Infection-Status_P7
Infection-Status_P8
Infection-Status_P9
Physical Exam

SDY3135: SARS-CoV-2 mRNA Vaccines Elicit Different Responses in Immunologically Naive and Pre-Immune Humans
Status: New
Description: As the COVID-19 pandemic continues, the authorization of vaccines for emergency use has been crucial in slowing down the rate of infection and transmission of the SARS-CoV-2 virus that causes COVID-19. In order to investigate the longitudinal serological responses to SARS-CoV-2 natural infection and vaccination, a large-scale, multi-year serosurveillance program entitled SPARTA (SARS SeroPrevalence and Respiratory Tract Assessment) was initiated at 4 locations in the U.S. The serological assay presented here measuring IgG binding to the SARS-CoV-2 receptor binding domain (RBD) detected antibodies elicited by SARS-CoV-2 infection or vaccination with a 95.5 percent sensitivity and a 95.9 percent specificity. We used this assay to screen more than 3100 participants and selected 20 previously infected pre-immune and 32 immunologically naive participants to analyze their antibody binding to RBD and viral neutralization (VN) responses following vaccination with two doses of either the Pfizer-BioNTech BNT162b2 or the Moderna mRNA-1273 vaccine. Vaccination not only elicited a more robust immune reaction than natural infection, but the level of neutralizing and anti-RBD antibody binding after vaccination is also significantly higher in pre-immune participants compared to immunologically naive participants (p less than 0.0033). Furthermore, the administration of the second vaccination did not further increase the neutralizing or binding antibody levels in pre-immune participants (p=0.69). However, approximately 46 percent of the immunologically naive participants required both vaccinations to seroconvert.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M3U0XLCFC1
Subjects: 74
Study PI, contact:
NameOrganizationSite
Ted Ross University of Georgia University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
David Forgacs University of Georgia University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Publications:
SARS-CoV-2 mRNA Vaccines Elicit Different Responses in Immunologically Naive and Pre-Immune Humans.. Frontiers in immunology Sep 2021. doi: 10.3389/fimmu.2021.728021 [Pubmed: 34646267]
Resources:
Frontiers in Immunology https://www.frontiersin.org/articles/10.3389/fimmu.2021.728021/full]
Assays:None
Clinical Assessments:
Immune_Status

SDY3155: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection
Status: New
Description: The investigators update the iNCOVACC vaccine, used in India, by creating ChAd-SARS-CoV-2-BA.5-S, which encodes a prefusion-stabilized BA.5 spike protein.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/M3BMG70SSV
Subjects: 352
Study PI, contact:
NameOrganizationSite
Michael Diamond Washington University School of Medicine Washington University School of Medicine, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Publications:
Mucosal vaccine-induced cross-reactive CD8(+) T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection.. Nature immunology Mar 2024. doi: 10.1038/s41590-024-01743-x [Pubmed: 38337035]
Resources:
Not Applicable Not Applicable]
Assays:
Assay TypeNumber of Exp. Samples
ELISA 805
Q-PCR 0
Virus Neutralization 598
Virus Plaque Assay 0
Clinical Assessments:
Physical Exam

SDY3158: Transient inhibition of lysosomal functions potentiates nucleic acid vaccines
Status: New
Description: Transient inhibition of lysosomal functions potentiates nucleic acid vaccines
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Duke CIVIC Vaccine Center (DCVC)
DOI: 10.21430/M3RLL6JH3E
Subjects: 0
Study PI, contact:
NameOrganizationSite
Michael Moody Duke University Duke University, Duke CIVICs Vaccine Center (DCVC)
Fan Yuan Duke University Duke University, Duke CIVICs Vaccine Center (DCVC)
Publications:
Transient inhibition of lysosomal functions potentiates nucleic acid vaccines.. Proceedings of the National Academy of Sciences of the United States of America Oct 2023. doi: 10.1073/pnas.2306465120 [Pubmed: 37871214]
Resources:
PNAS Link https://www.pnas.org/doi/10.1073/pnas.2306465120]
Assays:None
Clinical Assessments:None

SDY3159: B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S
Status: New
Description: The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people. Prior studies have shown that Ad26.COV2.S in_x0002_duces durable neutralizing antibodies (NAbs) that increase in coverage of variants over time, even in the absence of boosting or infection. Here, we studied humoral responses following Ad26.COV2.S vacci_x0002_nation in individuals enrolled in the initial Phase 1/2a trial of Ad26.COV2.S in 2020. Through 8 months post vaccination, serum NAb responses increased to variants, including B.1.351 (Beta) and B.1.617.2 (Delta), without additional boosting or infection. The level of somatic hypermutation, measured by nucleotide changes in the VDJ region of the heavy and light antibody chains, increased in Spike-specific B cells. Highly mutated mAbs from these sequences neutralized more SARS-CoV-2 variants than less mutated compara_x0002_tors. These findings suggest that the increase in NAb breadth over time following Ad26.COV2.S vaccina_x0002_tion is mediated by affinity maturation.
Program/Contract:
ProgramContract
SeroNet Immunologic Signatures of SARS-CoV-2 Vaccination and Disease
DOI: 10.21430/M3LSPNAZB6
Subjects: 0
Study PI, contact:
NameOrganizationSite
Dan Barouch Harvard Medical School Harvard Medical School
Catherine Jacob-dolan Harvard Medical School Harvard Medical School
Publications:
B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S.. iScience May 2024. doi: 10.1016/j.isci.2024.109716 [Pubmed: 38655202]
Resources:
Assays:None
Clinical Assessments:None

SDY3160: Durability of immunity and clinical protection in nursing home residents following bivalent SARS-CoV-2 vaccination
Status: New
Description: Background: Bivalent SARS-CoV-2 vaccines were developed to counter increasing susceptibility to emerging SARSCoV-2 variants. We evaluated the durability of immunity and protection following first bivalent vaccination among nursing home residents. Methods: We evaluated anti-spike and neutralization titers from blood in 653 community nursing home residents before and after each monovalent booster, and a bivalent vaccine. Concurrent clinical outcomes were evaluated using electronic health record data from a separate cohort of 3783 residents of Veterans Affairs (VA) nursing homes who had received at least the primary series monovalent vaccination. Using target trial emulation, we compared VA residents who did and did not receive the bivalent vaccine to measure vaccine effectiveness against infection, hospitalization, and death. Findings: In the community cohort, Omicron BA.5 neutralization activity rose after each monovalent and bivalent booster vaccination regardless of prior infection history. Titers declined over time but six months post-bivalent vaccination, BA.5 neutralization persisted at detectable levels in 75% of infection-naive and 98% of prior-infected individuals. In the VA nursing home cohort, bivalent vaccine added effectiveness to monovalent booster vaccination by 18.5% for infection (95% confidence interval (CI) −5.6, 34.0%), and 29.2% for hospitalization or death (95% CI −14.2, 56.2%) over five months.
Program/Contract:
ProgramContract
SeroNet Early Drivers of Humoral Immunity to SARS-CoV-2 Infections
DOI: 10.21430/M3TI74TSNW
Subjects: 0
Study PI, contact:
NameOrganizationSite
Christopher King Case Western Reserve University School of Medicine, Case Western Reserve University School of Medicine,
Brrigid Wilson Louis Stokes Cleveland Department of Veterans Affairs Medical Center Ggeriatric Research Education And Clinical Center
David Canaday Case Western Reserve University School of Medicine, Case Western Reserve University School of Medicine,
Publications:
Durability of immunity and clinical protection in nursing home residents following bivalent SARS-CoV-2 vaccination.. EBioMedicine Jul 2024. doi: 10.1016/j.ebiom.2024.105180 [Pubmed: 38861869]
Resources:
PMID38861869 Supplementary Data https://doi.org/10.1016/j.ebiom.2024.105180]
Assays:None
Clinical Assessments:None

SDY3162: SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination
Status: New
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines are effective at protecting from severe disease, but the protective antibodies wane rapidly even though SARS-CoV-2-specific plasma cells can be found in the bone marrow (BM). Here, to explore this paradox, we enrolled 19 healthy adults at 2.5–33 months after receipt of a SARS-CoV-2 mRNA vaccine and measured influenza-, tetanus- or SARS-CoV-2-specific antibody-secreting cells (ASCs) in long-lived plasma cell (LLPC) and non-LLPC subsets within the BM. Only influenza- and tetanus-specific ASCs were readily detected in the LLPCs, whereas SARS-CoV-2 specificities were mostly absent. The ratios of non-LLPC:LLPC for influenza, tetanus and SARS-CoV-2 were 0.61, 0.44 and 29.07, respectively. In five patients with known PCR-proven history of recent infection and vaccination, SARS-CoV-2-specific ASCs were mostly absent from the LLPCs. We show similar results with measurement for secreted antibodies from BM ASC culture supernatant. While serum IgG titers specific for influenza and tetanus correlated with IgG LLPCs, serum IgG levels for SARS-CoV-2, which waned within 3–6 months after vaccination, were associated with IgG non-LLPCs. In all, our studies suggest that rapid waning of SARS-CoV-2-specific serum antibodies could be accounted for by the absence of BM LLPCs after these mRNA vaccines.
Program/Contract:
ProgramContract
SeroNet Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
DOI: 10.21430/M3IM4HDSIR
Subjects: 0
Study PI, contact:
NameOrganizationSite
Ignacio Sanz Emory University Emory University
Frances Eun-hyung Lee Emory University Emory University
Natalie Haddad Emory University Emory University
Publications:
SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination.. Nature medicine Jan 2025. doi: 10.1038/s41591-024-03278-y [Pubmed: 39333316]
Resources:
Methods and supplementary data https://doi.org/10.1038/s41591-024-03278-y]
Assays:None
Clinical Assessments:None

SDY3164: Influenza vaccination response is associated with the DNA methylation of T cell pathways
Status: New
Description: Using multifactorial approach, the study explored the interaction between DNA methylation and the influenza vaccine response. Factors including age, BMI, and cell type proportions were evaluated, leading to the identification of key methylation sites associated with RIG-I signaling and genes involved in innate immunity ro viruses. The longitudinal study included a subset of 42 participants vaccinated with Fluzone, enrolled in UGA5 and had previously been part of the UGA4 season.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M38DJZGGZY
Subjects: 0
Study PI, contact:
NameOrganizationSite
Elaine Reed University of California at Los Angeles University of California at Los Angeles, CIVR-HRP
Publications:
The response to influenza vaccination is associated with DNA methylation-driven regulation of T cell innate antiviral pathways.. Research square May 2024. doi: 10.21203/rs.3.rs-4324518/v1 [Pubmed: 38826189]
Resources:
PubMed https://pubmed.ncbi.nlm.nih.gov/38826189/]
Assays:None
Clinical Assessments:None

SDY3165: COBRA rHAs adjuvanted with Infectimune generate broadly protective antibody responses in animals
Status: New
Description: The goal of the study was to investigate whether the use of Infectimune combined with COBRA recombinant HA (rHA) proteins could increase the antibody response, compared to using the COBRA rHA alone, especially in mice with pre-existing influenza immunity. Animals were vaccinated with different doses of COBRA rHA to evalaute the dose-sparing effects of the adjuvant. COBRA rHA vaccines (with and without adjuvant) were also compared to vaccines using wild-type rHA proteins. Sera was collected from animals for serological assays, such as microneutralization, HAI and ELISA. Lung and nasal washes were colleted to determine the viral load by plaque assay.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M3G9COVSH1
Subjects: 73
Study PI, contact:
NameOrganizationSite
Jessica Medina Cleveland Clinic Cleveland Clinic, CIVR-HRP
Ted Ross Cleveland Clinic Cleveland Clinic, CIVR-HRP
Matthew Thomas Cleveland Clinic Cleveland Clinic, CIVR-HRP
James Allen Cleveland Clinic Cleveland Clinic, CIVR-HRP
Amanda Lynch Cleveland Clinic Cleveland Clinic, CIVR-HRP
Publications:
Computationally Optimized Hemagglutinin Proteins Adjuvanted with Infectimune(R) Generate Broadly Protective Antibody Responses in Mice and Ferrets.. Vaccines Dec 2024. doi: 10.3390/vaccines12121364 [Pubmed: 39772026]
Resources:
Article in PubMed Central https://pmc.ncbi.nlm.nih.gov/articles/pmid/39772026/]
Assays:None
Clinical Assessments:
Physical Exam

SDY3168: Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19
Status: New
Description: Pre-existing anti-interferon alpha (anti-IFN-α) autoantibodies in blood are associated with susceptibility to life-threatening coronavirus disease 2019 (COVID-19). However, it is unclear whether anti-IFN-α autoantibodies in the airways, the initial site of infection, can also determine disease outcomes. In this study, we developed a multiparameter technology, FlowBEAT, to Pre-existing anti-interferon alpha (anti-IFN-α) autoantibodies in blood are associated with susceptibility to life-threatening coronavirus disease 2019 (COVID-19). However, it is unclear whether anti-IFN-α autoantibodies in the airways, the initial site of infection, can also determine disease outcomes. In this study, we developed a multiparameter technology, FlowBEAT, to quantify and profile the isotypes of anti-severe acute respiratory syndrome coronavirus 2 (SARS_x0002_CoV-2) and anti-IFN-α antibodies in longitudinal samples collected over 20 months from the airways and blood of 125 donors spanning mild to severe COVID-19. We found that nasal IgA1 anti-IFN-α autoantibodies were induced post-infection onset in more than 70% of mild and moderate COVID-19 cases and were associated with robust anti-SARS-CoV-2 immunity, fewer symptoms, and efficient recovery. Nasal anti-IFN-α autoantibodies followed the peak of host IFN-α production and waned with disease recovery, revealing a regulated balance between IFN-α and anti-IFN-α response. In contrast, systemic IgG1 anti-IFN-α autoantibodies appeared later and were detected only in a subset of patients with elevated systemic inflammation and worsening symptoms. These data reveal a protective role for nasal anti-IFN-α in the immunopathology of COVID-19 and suggest that anti-IFN-α autoantibodies may serve a homeostatic function to regulate host IFN-α following viral infection in the respiratory mucosa.
Program/Contract:
ProgramContract
SeroNet Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
DOI: 10.21430/M3BAGG41K1
Subjects: 0
Study PI, contact:
NameOrganizationSite
Frances Eun-hyung Lee Emory University Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Lowance Ct. for Human Immunology
Ignacio Sanz Emory University Division of Immunology And Rheumatology, Lowance Center For Human Immunology
Ghosn Eliver E. B. Emory University Emory Vaccine Center, Emory National Primate Research Center
Publications:
Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19.. Science translational medicine Nov 2024. doi: 10.1126/scitranslmed.adq1789 [Pubmed: 39504354]
Resources:
Ghosn Lab GitHub github.com/Ghosn-Lab/FlowBEAT]
Zenodo doi.org/10.5281/zenodo.1388696]
Assays:None
Clinical Assessments:None

SDY3170: Causal Estimands for Analyses of Averted and Avertible Outcomes due to Infectious Disease Interventions
Status: New
Description: During the coronavirus disease (COVID-19) pandemic, researchers attempted to estimate the number of averted and avertible outcomes due to vaccination campaigns to quantify public health impact. However, the estimands used in these analyses have not been previously formalized. It is also unclear how these analyses relate to the broader framework of direct, indirect, total, and overall causal effects under interference. Here, using potential outcome notation, we adjust the direct and overall effects to accommodate analyses of averted and avertible outcomes. We use this framework to interrogate the commonly held assumption that vaccine-averted outcomes via direct impact among vaccinated individuals (or vaccine-avertible outcomes via direct impact among unvaccinated individuals) is a lower bound on vaccine-averted (or -avertible) outcomes overall. To do so, we describe a susceptible-infected-recovered-death model stratified by vaccination status. When vaccine efficacies wane, the lower bound fails for vaccine-avertible outcomes. When transmission or fatality parameters increase over time, the lower bound fails for both vaccine-averted and -avertible outcomes. Only in the simplest scenario where vaccine efficacies, transmission, and fatality parameters are constant over time, outcomes averted via direct impact among vaccinated individuals (or outcomes avertible via direct impact among unvaccinated individuals) is a lower bound on overall impact. In conclusion, the lower bound can fail under common violations to assumptions on time-invariant vaccine efficacy, pathogen properties, or behavioral parameters. In real data analyses, estimating what seems like a lower bound on overall impact through estimating direct impact may be inadvisable without examining the directions of indirect effects
Program/Contract:
ProgramContract
SeroNet Casual, Statistical and Mathematical Modeling with Serologic Data
DOI: 10.21430/M3QTQ0FPKH
Subjects: 0
Study PI, contact:
NameOrganizationSite
Marc Lipsitch Harvard T.h. Chan School of Public Health Center For Communicable Disease Dynamics, Department of Epidemiology
Christopher B Boyer Harvard T.h. Chan School of Public Health Center For Communicable Disease Dynamics, Department of Epidemiology
Publications:
Causal Estimands for Analyses of Averted and Avertible Outcomes due to Infectious Disease Interventions.. Epidemiology (Cambridge, Mass.) May 2025. doi: 10.1097/EDE.0000000000001839 [Pubmed: 39855261]
Resources:
Katjia GitHub Impact Estimands https://github.com/katjia/impact_estimands]
Time-invariant parameters http://links.lww.com/EDE/C222]
Assays:None
Clinical Assessments:None

SDY3172: Pre-Existing Human Antibody Repertoire
Status: New
Description: Not Provided
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M3MZVV06R5
Subjects: 0
Study PI, contact:
NameOrganizationSite
Kaito Nagashima University of Georgia University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Ted Ross University of Georgia University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Publications:
The Pre-Existing Human Antibody Repertoire to Computationally Optimized Influenza H1 Hemagglutinin Vaccines.. Journal of immunology (Baltimore, Md. : 1950) Jul 2022. doi: 10.4049/jimmunol.2101171 [Pubmed: 35697384]
Resources:
Not Applicable Not Applicable]
Assays:None
Clinical Assessments:None

Updated Studies

SDY1644: Urban Environmental Factors and Childhood Asthma (URECA) (ICAC-07)
Status: Updated
Description: The purpose of this study is to determine the way environmental factors (like the components of inner-city household dust) affect immune system development and symptoms of asthma in inner city children. The study is divided into three periods, as the subjects age from birth to 10 years old. Each age bracket will explore different objectives and endpoints. Study Objectives/Hypotheses: Subjects age 0 to 3 years old: Environmental factors in the inner city adversely influence the development of the immune system to promote cytokine dysregulation, allergy, and recurrent wheezing by age 3. Children who have had a viral lower respiratory infection and have developed cytokine dysregulation by age 3 are at increased risk for the development of asthma by age 6. Subjects age 4 to 7 years old: There is a unique pattern of immune development that is driven by specific urban exposures in early life, and this pattern of immune development is characterized by: 1) impairment of antiviral responses and 2) accentuation of Th2-like responses (e.g. cockroach-specific Interleukin-13(IL-13)). The clinical effects of these changes in immune development are frequent virus-induced wheezing and allergic sensitization by 3-4 years of age, and these characteristics synergistically increase the risk of asthma at age 7 years. Subjects age 7 to 10 years old: There are unique combinations of environmental exposures (cockroach allergens, indoor pollutants [Environmental Tobacco Smoke (ETS) and Nitrogen Dioxide (NO2)], lack of microbial exposure), and family characteristics (stress, genetic factors related to innate immunity) that synergistically promote asthma onset, persistence, and morbidity in urban neighborhoods. These exposures and characteristics influence immune expression and lung development during critical periods of growth, resulting in specific asthma phenotypes. Subjects age 10 to 16 years old: To determine the wheezing, asthma and atopy phenotypes in minority children growing up in poor urban neighborhoods as they develop from birth through adolescence.
Program/Contract:
ProgramContract
Inner City Asthma Consortium (ICAC) RFA-AI-13-036 INNER CITY ASTHMA CONSORTIUM 3 (ICAC3)
DOI: 10.21430/M3H1YHLR5Z
Subjects: 1218
Study PI, contact:
NameOrganizationSite
James Gern University of Wisconsin School of Medicine and Public Health University of Wisconsin School of Medicine and Public Health
Publications:
Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study.. BMC immunology Dec 2006. doi: 10.1186/1471-2172-7-29 [Pubmed: 17156490]
The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population.. BMC pulmonary medicine May 2009. doi: 10.1186/1471-2466-9-17 [Pubmed: 19426496]
Characterization of regulatory T cells in urban newborns.. Clinical and molecular allergy : CMA Jul 2009. doi: 10.1186/1476-7961-7-8 [Pubmed: 19586545]
Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses.. The Journal of allergy and clinical immunology Nov 2009. doi: 10.1016/j.jaci.2009.08.021 [Pubmed: 19895995]
Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort.. American journal of respiratory and critical care medicine Jul 2010. doi: 10.1164/rccm.200904-0637OC [Pubmed: 20194818]
Retention strategies and predictors of attrition in an urban pediatric asthma study.. Clinical trials (London, England) Aug 2010. doi: 10.1177/1740774510373798 [Pubmed: 20571137]
Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study).. The Journal of allergy and clinical immunology Apr 2011. doi: 10.1016/j.jaci.2010.12.1122 [Pubmed: 21333343]
Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the Urban Environment and Childhood Asthma study.. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Jun 2011. doi: 10.1111/j.1365-2222.2011.03712.x [Pubmed: 21481021]
Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort.. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Mar 2012. doi: 10.1111/j.1365-2222.2011.03882.x [Pubmed: 22092655]
Antiviral IFN-g responses of monocytes at birth predict respiratory tract illness in the first year of life.. The Journal of allergy and clinical immunology May 2012. doi: 10.1016/j.jaci.2012.02.033 [Pubmed: 22460071]
Comparison of the etiology of viral respiratory illnesses in inner-city and suburban infants.. The Journal of infectious diseases Nov 2012. doi: 10.1093/infdis/jis504 [Pubmed: 23014674]
Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children.. The Journal of allergy and clinical immunology Sep 2014. doi: 10.1016/j.jaci.2014.04.018 [Pubmed: 24908147]
Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort.. The Journal of allergy and clinical immunology Jan 2015. doi: 10.1016/j.jaci.2014.06.033 [Pubmed: 25129677]
Relation between stress and cytokine responses in inner-city mothers.. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Nov 2015. doi: 10.1016/j.anai.2015.07.021 [Pubmed: 26409873]
The influence of atopy and asthma on immune responses in inner-city adults.. Immunity, inflammation and disease Mar 2016. doi: 10.1002/iid3.96 [Pubmed: 27042305]
Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families.. American journal of respiratory and critical care medicine Mar 2017. doi: 10.1164/rccm.201602-0272OC [Pubmed: 27654103]
Asthma phenotypes in inner-city children.. The Journal of allergy and clinical immunology Oct 2016. doi: 10.1016/j.jaci.2016.06.061 [Pubmed: 27720016]
Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy.. The Journal of allergy and clinical immunology Sep 2017. doi: 10.1016/j.jaci.2016.10.052 [Pubmed: 28089873]
Early-life home environment and risk of asthma among inner-city children.. The Journal of allergy and clinical immunology Apr 2018. doi: 10.1016/j.jaci.2017.06.040 [Pubmed: 28939248]
Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment.. Journal of immunology (Baltimore, Md. : 1950) Mar 2018. doi: 10.4049/jimmunol.1701525 [Pubmed: 29431692]
Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy.. The journal of allergy and clinical immunology. In practice Sep 2018. doi: 10.1016/j.jaip.2017.12.028 [Pubmed: 29449165]
Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma.. The Journal of allergy and clinical immunology Dec 2018. doi: 10.1016/j.jaci.2018.02.019 [Pubmed: 29518416]
Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort.. American journal of respiratory and critical care medicine Jan 2019. doi: 10.1164/rccm.201801-0190OC [Pubmed: 30079758]
Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels.. Epigenetics Jun 2021. doi: 10.1080/15592294.2020.1817290 [Pubmed: 32997571]
Endotype of allergic asthma with airway obstruction in urban children.. The Journal of allergy and clinical immunology Nov 2021. doi: 10.1016/j.jaci.2021.02.040 [Pubmed: 33713771]
Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.. Genome medicine May 2022. doi: 10.1186/s13073-022-01058-2 [Pubmed: 35606880]
Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.. PLoS genetics Jan 2023. doi: 10.1371/journal.pgen.1010594 [Pubmed: 36638096]
Resources:
ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT00114881]
SRA SRP102104 https://trace.ncbi.nlm.nih.gov/Traces/?view=study&acc=SRP102104]
GEO GSE96783 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96783]
BioProject https://www.ncbi.nlm.nih.gov/bioproject/PRJNA379624]
SRA SRP249918 https://trace.ncbi.nlm.nih.gov/Traces/?view=study&acc=SRP249918]
GEO GSE145505 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE145505]
BioProject https://www.ncbi.nlm.nih.gov/bioproject/PRJNA607333]
dbGaP https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002921.v2.p1]
GEO GSE132181 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE132181]
BioProject https://www.ncbi.nlm.nih.gov/bioproject/PRJNA546267]
Related study - SDY1025 https://www.immport.org/shared/search?text=sdy1025]
Assays:
Assay TypeNumber of Exp. Samples
DNA methylation profiling assay 392
RNA sequencing 866
Clinical Assessments:
asthma primary definition
Baby Birth Record
Child Bedroom Environment
Daycare Environment
Heating and Appliances in Home
Home dust allergen levels and assays
Home Environmental Issues
Home Smoking Environment
Maternal Alcohol Use History
Maternal Smoking History
Medical Record During Labor and Delivery
Medical Record During Pregnancy
Other Residence Environment
Overall Animal Exposure
Spirometry
Spirometry Reversibility

SDY2299: UFDI HIP
Status: Updated
Description: Standardized flow cytometric immune profiling on peripheral blood from a cross-sectional cohort of T1D patients (N=240), their first-degree relatives (N=310), pre-T1D with two or more islet autoantibodies (N=24), and autoantibody negative healthy controls (N=252).
Program/Contract:
ProgramContract
NIH Program Immune Function And The Progression To Type 1 Diabetes
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M3Y99ZG0JN
Subjects: 826
Study PI, contact:
NameOrganizationSite
Todd Brusko University of Florida University of Florida
Rhonda Bacher University of Florida University of Florida
Melanie Shapiro University of Florida University of Florida
Xiaoru Dong University of Florida University of Florida
Daniel Perry University of Florida University of Florida
Puchong Thirawatananond University of Florida University of Florida
Publications:
Human immune phenotyping reveals accelerated aging in type 1 diabetes. JCI Insight. Sep 2023. doi: 10.1172/jci.insight.170767 [Pubmed: 37498686]
Resources:
Assays:
Assay TypeNumber of Exp. Samples
Flow Cytometry 826
Clinical Assessments:None

SDY2320: Immunity induced by vaccination with recombinant influenza B virus neuraminidase protein breaks viral transmission chains in guinea pigs in an exposure intensity-dependent manner
Status: Updated
Description: The authors investigated if recombinant influenza virus neuraminidase (NA) vaccines delivered at a mucosal site could protect from onward transmission of influenza B viruses in the guinea pig model.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/M35P75OQ1V
Subjects: 84
Study PI, contact:
NameOrganizationSite
Florian Krammer Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Publications:
Immunity induced by vaccination with recombinant influenza B virus neuraminidase protein breaks viral transmission chains in guinea pigs in an exposure intensity-dependent manner. J Virol. Oct 2023. doi: 10.1128/jvi.01057-23 [Pubmed: 37800945]
Resources:
Not Applicable Not Applicable]
Assays:
Assay TypeNumber of Exp. Samples
ELISA 180
Other 442
Clinical Assessments:None

SDY2398: Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infection
Status: Updated
Description: Here, the investigators analyzed samples from the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2) study and measured serum IgG, saliva IgG and saliva secretory IgA responses in individuals who experienced breakthrough infections and who received COVID-19 mRNA booster vaccinations.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/M3JDI4T17W
Subjects: 111
Study PI, contact:
NameOrganizationSite
Viviana Simon Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Florian Krammer Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Publications:
Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infection. mBio Dec 2023. doi: 10.1128/mbio.02280-23 [Pubmed: 38092666]
Resources:
Not Applicable Not Applicable]
Assays:
Assay TypeNumber of Exp. Samples
ELISA 661
Clinical Assessments:None

SDY2412: The post-COVID-19 population has a high prevalence of cross-reactive antibodies to spikes from all Orthocoronavirinae genera
Status: Updated
Description: Here, the investigators report that infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces broadly cross-reactive binding antibodies to spikes from a wide range of coronaviruses.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/M3YZAEH2H6
Subjects: 118
Study PI, contact:
NameOrganizationSite
Viviana Simon Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Florian Krammer Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Publications:
The post-COVID-19 population has a high prevalence of cross-reactive antibodies to spikes from all�Orthocoronavirinae�genera. mBio Jan 2024. doi: 10.1128/mbio.02250-23 [Pubmed: 38112467]
Resources:
Not Applicable Not Applicable]
Link to SeroNet SDY2843 https://immport.org/shared/study/SDY2843]
Assays:
Assay TypeNumber of Exp. Samples
ELISA 3317
Clinical Assessments:
Assessment-Panel-1

SDY2466: SARS-CoV-2 BA.1 and BA.2 breakthrough infections boost antibody responses to early Omicron subvariants but not BQ.1.1 and XBB.1.5
Status: Updated
Description: Here, the authors describe the potency and breadth of neutralizing and binding antibody responses against a large panel of VOC following an Omicron BA.1 or BA.2 breakthrough infection in a heterogeneous cohort of individuals with diverse exposure histories.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/m3qke0o5vy
Subjects: 67
Study PI, contact:
NameOrganizationSite
Anass Abbad Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Florian Krammer Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Publications:
SARS-CoV-2 BA.1 and BA.2 breakthrough infections boost antibody responses to early Omicron subvariants but not BQ.1.1 or XBB.1.5. Cell Rep Med. Mar 2024. doi: 10.1016/j.xcrm.2024.101474 [Pubmed: 38508136]
Resources:
Not Applicable Not Applicable]
Assays:
Assay TypeNumber of Exp. Samples
ELISA 2722
Virus Neutralization 2128
Clinical Assessments:
Assessment-Panel-PBT-01
Assessment-Panel-PBT-02
Assessment-Panel-PBT-05
Assessment-Panel-PBT-06
Assessment-Panel-PBT-07
Assessment-Panel-PBT-08
Assessment-Panel-PBT-09
Assessment-Panel-PBT-11
Assessment-Panel-PBT-12
Assessment-Panel-PBT-13
Assessment-Panel-PBT-14
Assessment-Panel-PBT-15
Assessment-Panel-PBT-16
Assessment-Panel-PBT-17
Assessment-Panel-PBT-20
Assessment-Panel-PBT-21
Assessment-Panel-PBT-23
Assessment-Panel-PBT-24
Assessment-Panel-PBT-25
Assessment-Panel-PBT-26
Assessment-Panel-PBT-27
Assessment-Panel-PBT-28
Assessment-Panel-PBT-29
Assessment-Panel-PBT-30
Assessment-Panel-PBT-31
Assessment-Panel-PBT-32
Assessment-Panel-PBT-34
Assessment-Panel-PBT-39
Assessment-Panel-PBT-40
Assessment-Panel-PBT-41
Assessment-Panel-PBT-42
Assessment-Panel-PBT-45
Assessment-Panel-PBT-46
Assessment-Panel-PBT-48
Assessment-Panel-PBT-51
Assessment-Panel-PBT-52
Assessment-Panel-PBT-53
Assessment-Panel-PBT-54
Assessment-Panel-PBT-55
Assessment-Panel-PBT-56
Assessment-Panel-PBT-57
Assessment-Panel-PBT-59
Assessment-Panel-PBT-60
MedicalHistory_PBT-03
MedicalHistory_PBT-10
MedicalHistory_PBT-18
MedicalHistory_PBT-19
MedicalHistory_PBT-22
MedicalHistory_PBT-33
MedicalHistory_PBT-35
MedicalHistory_PBT-36
MedicalHistory_PBT-37
MedicalHistory_PBT-38
MedicalHistory_PBT-43
MedicalHistory_PBT-44
MedicalHistory_PBT-47
MedicalHistory_PBT-49
MedicalHistory_PBT-50
MedicalHistory_PBT-58
MedicalHistory_PBT-61
MedicalHistory_PBT-62
MedicalHistory_PBT-63
MedicalHistory_PBT-64
MedicalHistory_PBT-65
MedicalHistory_PBT-66
MedicalHistory_PBT-67
MedicalHistory_PBT-68

SDY2468: Kinetics and durability of humoral responses to SARS-CoV-2 infection and vaccination
Status: Updated
Description: Using the PARIS longitudinal cohort, the authors determined the kinetics of antibody responses to spike protein after infections, during the primary immunization series, during monovalent and bivalent booster vaccination as well as during breakthrough infections.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/M37GAKH32A
Subjects: 825
Study PI, contact:
NameOrganizationSite
Viviana Simon Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
Publications:
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase. Immunity. Mar 2024. doi: 10.1016/j.immuni.2024.01.017 [Pubmed: 38395697]
Resources:
Not Applicable Not Applicable]
Assays:
Assay TypeNumber of Exp. Samples
ELISA 4551
Clinical Assessments:
Breakthrou_PARIS-003
Breakthrou_PARIS-004
Breakthrou_PARIS-007
Breakthrou_PARIS-008
Breakthrou_PARIS-009
Breakthrou_PARIS-010
Breakthrou_PARIS-011
Breakthrou_PARIS-013
Breakthrou_PARIS-014
Breakthrou_PARIS-016
Breakthrou_PARIS-017
Breakthrou_PARIS-019
Breakthrou_PARIS-020
Breakthrou_PARIS-022
Breakthrou_PARIS-026
Breakthrou_PARIS-028
Breakthrou_PARIS-030
Breakthrou_PARIS-031
Breakthrou_PARIS-032
Breakthrou_PARIS-034
Breakthrou_PARIS-035
Breakthrou_PARIS-036
Breakthrou_PARIS-038
Breakthrou_PARIS-039
Breakthrou_PARIS-040
Breakthrou_PARIS-041
Breakthrou_PARIS-044
Breakthrou_PARIS-045
Breakthrou_PARIS-047
Breakthrou_PARIS-050
Breakthrou_PARIS-051
Breakthrou_PARIS-053
Breakthrou_PARIS-054
Breakthrou_PARIS-056
Breakthrou_PARIS-057
Breakthrou_PARIS-059
Breakthrou_PARIS-064
Breakthrou_PARIS-069
Breakthrou_PARIS-072
Breakthrou_PARIS-074
Breakthrou_PARIS-075
Breakthrou_PARIS-076
Breakthrou_PARIS-077
Breakthrou_PARIS-079
Breakthrou_PARIS-082
Breakthrou_PARIS-083
Breakthrou_PARIS-084
Breakthrou_PARIS-085
Breakthrou_PARIS-086
Breakthrou_PARIS-087
Breakthrou_PARIS-091
Breakthrou_PARIS-097
Breakthrou_PARIS-098
Breakthrou_PARIS-099
Breakthrou_PARIS-100
Breakthrou_PARIS-102
Breakthrou_PARIS-103
Breakthrou_PARIS-104
Breakthrou_PARIS-105
Breakthrou_PARIS-106
Breakthrou_PARIS-110
Breakthrou_PARIS-113
Breakthrou_PARIS-114
Breakthrou_PARIS-116
Breakthrou_PARIS-120
Breakthrou_PARIS-124
Breakthrou_PARIS-125
Breakthrou_PARIS-128
Breakthrou_PARIS-129
Breakthrou_PARIS-131
Breakthrou_PARIS-132
Breakthrou_PARIS-136
Breakthrou_PARIS-137
Breakthrou_PARIS-139
Breakthrou_PARIS-141
Breakthrou_PARIS-145
Breakthrou_PARIS-147
Breakthrou_PARIS-151
Breakthrou_PARIS-152
Breakthrou_PARIS-155
Breakthrou_PARIS-157
Breakthrou_PARIS-160
Breakthrou_PARIS-162
Breakthrou_PARIS-163
Breakthrou_PARIS-164
Breakthrou_PARIS-165
Breakthrou_PARIS-171
Breakthrou_PARIS-172
Breakthrou_PARIS-173
Breakthrou_PARIS-174
Breakthrou_PARIS-176
Breakthrou_PARIS-177
Breakthrou_PARIS-179
Breakthrou_PARIS-180
Breakthrou_PARIS-181
Breakthrou_PARIS-183
Breakthrou_PARIS-184
Breakthrou_PARIS-186
Breakthrou_PARIS-187
Breakthrou_PARIS-188
Breakthrou_PARIS-189
Breakthrou_PARIS-191
Breakthrou_PARIS-192
Breakthrou_PARIS-195
Breakthrou_PARIS-199
Breakthrou_PARIS-207
Breakthrou_PARIS-210
Breakthrou_PARIS-211
Breakthrou_PARIS-214
Breakthrou_PARIS-217
Breakthrou_PARIS-218
Breakthrou_PARIS-221
Breakthrou_PARIS-225
Breakthrou_PARIS-227
Breakthrou_PARIS-228
Breakthrou_PARIS-232
Breakthrou_PARIS-233
Breakthrou_PARIS-237
Breakthrou_PARIS-239
Breakthrou_PARIS-240
Breakthrou_PARIS-249
Breakthrou_PARIS-250
Breakthrou_PARIS-254
Breakthrou_PARIS-260
Breakthrou_PARIS-267
Breakthrou_PARIS-292
Breakthrou_PARIS-293
Breakthrou_PARIS-295
Breakthrou_PARIS-297
Breakthrou_PARIS-300
Breakthrou_PARIS-308
PreImmunity_PARIS-037
PreImmunity_PARIS-049
PreImmunity_PARIS-052
PreImmunity_PARIS-068
PreImmunity_PARIS-090
PreImmunity_PARIS-092
PreImmunity_PARIS-107
PreImmunity_PARIS-109
PreImmunity_PARIS-122
PreImmunity_PARIS-123
PreImmunity_PARIS-133
PreImmunity_PARIS-138
PreImmunity_PARIS-142
PreImmunity_PARIS-143
PreImmunity_PARIS-144
PreImmunity_PARIS-154
PreImmunity_PARIS-161
PreImmunity_PARIS-175
PreImmunity_PARIS-182
PreImmunity_PARIS-184
PreImmunity_PARIS-198
PreImmunity_PARIS-200
PreImmunity_PARIS-202
PreImmunity_PARIS-203
PreImmunity_PARIS-208
PreImmunity_PARIS-213
PreImmunity_PARIS-215
PreImmunity_PARIS-220
PreImmunity_PARIS-226
PreImmunity_PARIS-229
PreImmunity_PARIS-230
PreImmunity_PARIS-234
PreImmunity_PARIS-236
PreImmunity_PARIS-242
PreImmunity_PARIS-244
PreImmunity_PARIS-248
PreImmunity_PARIS-252
PreImmunity_PARIS-253
PreImmunity_PARIS-255
PreImmunity_PARIS-256
PreImmunity_PARIS-257
PreImmunity_PARIS-258
PreImmunity_PARIS-259
PreImmunity_PARIS-261
PreImmunity_PARIS-262
PreImmunity_PARIS-264
PreImmunity_PARIS-265
PreImmunity_PARIS-266
PreImmunity_PARIS-269
PreImmunity_PARIS-270
PreImmunity_PARIS-271
PreImmunity_PARIS-272
PreImmunity_PARIS-273
PreImmunity_PARIS-274
PreImmunity_PARIS-275
PreImmunity_PARIS-278
PreImmunity_PARIS-279
PreImmunity_PARIS-280
PreImmunity_PARIS-281
PreImmunity_PARIS-282
PreImmunity_PARIS-283
PreImmunity_PARIS-284
PreImmunity_PARIS-285
PreImmunity_PARIS-286
PreImmunity_PARIS-287
PreImmunity_PARIS-288
PreImmunity_PARIS-289
PreImmunity_PARIS-291
PreImmunity_PARIS-294
PreImmunity_PARIS-296
PreImmunity_PARIS-298
PreImmunity_PARIS-299
PreImmunity_PARIS-301
PreImmunity_PARIS-302
PreImmunity_PARIS-303
PreImmunity_PARIS-304
PreImmunity_PARIS-306
PreImmunity_PARIS-307
PreImmunity_PARIS-309
PreImmunity_PARIS-310
PreImmunity_PARIS-311
PreImmunity_PARIS-313
PreImmunity_PARIS-314
PreImmunity_PARIS-315
PreImmunity_PARIS-316
PreImmunity_PARIS-317
PreImmunity_PARIS-318
PreImmunity_PARIS-319
PreImmunity_PARIS-320
PreImmunity_PARIS-321
PreImmunity_PARIS-322
PreImmunity_PARIS-323
PreImmunity_PARIS-324
PreImmunity_PARIS-325
PreImmunity_PARIS-326
PreImmunity_PARIS-327
PreImmunity_PARIS-328
PreImmunity_PARIS-329
PreImmunity_PARIS-330
PreImmunity_PARIS-331
PreImmunity_PARIS-332
PreImmunity_PARIS-334
PreImmunity_PARIS-335
PreImmunity_PARIS-337
PreImmunity_PARIS-338
PreImmunity_PARIS-339
PreImmunity_PARIS-340
PreImmunity_PARIS-341
PreImmunity_PARIS-342
PreImmunity_PARIS-343
PreImmunity_PARIS-344
PreImmunity_PARIS-345
PreImmunity_PARIS-346
PreImmunity_PARIS-347
PreImmunity_PARIS-348
PreImmunity_PARIS-349
PreImmunity_PARIS-350
PreImmunity_PARIS-351
PreImmunity_PARIS-352
PreImmunity_PARIS-353
PreImmunity_PARIS-354
PreImmunity_PARIS-355
PreImmunity_PARIS-356
PreImmunity_PARIS-357
PreImmunity_PARIS-358
PreImmunity_PARIS-359

SDY2673: Next Generation Methodology for Updating Computationally Optimized Broadly Reactive Antigen (COBRA) HA Vaccines Against Emerging Human Seasonal Influenza A(H3N2) Viruses
Status: Updated
Description: Seasonal influenza vaccines typically consist of wild-type influenza A and B viruses that are limited in their ability to elicit protective immune responses against co-circulating influenza virus variant strains. Improved influenza virus vaccines need to elicit protective immune responses against multiple influenza virus drift variants within each season. Broadly reactive vaccine candidates potentially provide a solution to this problem, but their efficacy may begin to wane as influenza viruses naturally mutate through processes that mediates drift. Thus, it is necessary to develop a method that commercial vaccine manufacturers can use to update broadly reactive vaccine antigens to better protect against future and currently circulating viral variants. Building upon the COBRA technology, nine next-generation H3N2 influenza hemagglutinin (HA) vaccines were designed using a next generation algorithm and design methodology. These next-generation broadly reactive COBRA H3 HA vaccines were superior to wild-type HA vaccines at eliciting antibodies with high HAI activity against a panel of historical and co-circulating H3N2 influenza viruses isolated over the last 15 years, as well as the ability to neutralize future emerging H3N2 isolates.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M388O87C8Y
Subjects: 274
Study PI, contact:
NameOrganizationSite
James Allen University of Georgia University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Ted Ross University of Georgia University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Publications:
Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses.. Scientific reports Mar 2021. doi: 10.1038/s41598-020-79590-7 [Pubmed: 33654128]
Resources:
Not Applicable https://pubmed.ncbi.nlm.nih.gov/33654128/]
Assays:
Assay TypeNumber of Exp. Samples
Hemagglutination Inhibition 2528
Virus Neutralization 150
Clinical Assessments:None

SDY2751: Multi-subtype protection N1 Vaccination
Status: Updated
Description: Protection induced by vaccination with the computationally optimized broadly reactive NA antigen (N1-I COBRA NA) was characterized in both influenza serologically naive and pre-immune ferret models following H1N1 viral challenge.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M3QYG9MI3P
Subjects: 195
Study PI, contact:
NameOrganizationSite
Ted Ross University of Georgia University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Publications:
Multi-Influenza HA Subtype Protection of Ferrets Vaccinated with an N1 COBRA-Based Neuraminidase.. Viruses Jan 2023. doi: 10.3390/v15010184 [Pubmed: 36680224]
Resources:
mdpi.com https://www.mdpi.com/1999-4915/15/1/184]
Assays:None
Clinical Assessments:
Not Applicable

SDY2839: Advax adjuvanted COBRA vaccines
Status: Updated
Description: Evaluate the immune response induced by Advax-SM adjuvant in combination with broadly reactive influenza hemagglutinin (HA) vaccines in mouse model and to investigate how these responses elicit the most protective immune responses against H1N1 and H3N2 influenza viruses.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M3UD76FFV9
Subjects: 72
Study PI, contact:
NameOrganizationSite
Ted Ross Other: Cleveland Clinic University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Publications:
Advax-SM™-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines.. Vaccines Apr 2024. doi: 10.3390/vaccines12050455 [Pubmed: 38793706]
Resources:
Not Applicable https://www.mdpi.com/2076-393X/12/5/455]
Assays:None
Clinical Assessments:
Not Applicable

SDY2943: Treg Adoptive Therapy in Subclinical Inflammation in Kidney Transplantation
Status: Updated
Description: This is an open-label trial to determine the safety and efficacy of a single dose of autologous polyTregs in renal transplant recipients with SCI in the 3-7 months post-transplant allograft biopsy compared to control patients treated with CNI-based immunosuppression. The efficacy of the Treg therapy will be assessed by the reduction of graft inflammation on biopsies performed at 7 months after study group allocation compared to the eligibility biopsy. The original study design included an additional treatment arm with a single dose of darTregs. However, due to the inability to manufacture an adequate number of cells for infusion, this treatment arm was removed from the study in protocol version 9.0. One subject was treated in the darTreg arm and completed follow-up prior to the arm being removed from the protocol. The accrual goal for the study was reduced due to the removal of this arm as well as challenges associated with recruitment of participants in the setting of the COVID-19 pandemic. Given that this is primarily a pilot, proof-of-concept, we believe that the target of 7 evaluable participants in each arm is sufficient to provide the necessary clinical and mechanistic data that will allow us to assess the impact of polyTregs on graft inflammation.
Program/Contract:
ProgramContract
Clinical Trials in Organ Transplantation (CTOT) Applying precision MEdicine to optimize desensitization with noveL bIOlogics or cellular theRApies in highly sensiTized kidney transplant patiEnts (AMELIORATE)
DOI: 10.21430/M36RLSSI99
Subjects: 16
Study PI, contact:
NameOrganizationSite
Flavio Vincenti UCSF UCSF
Publications:None
Resources:
Assays:None
Clinical Assessments:
Acute Antibody-Mediated Rejection_1
Acute Antibody-Mediated Rejection_2
Acute Cellular Rejection_1
Acute Cellular Rejection_2
Arteriolar Hyalin_1
Arteriolar Hyalin_2
Borderline Change_1
Borderline Change_2
Chronic Active AMR_1
Chronic Active AMR_2
CMV IgG antibody Result
CMV IgM antibody Result
EBV IgG Antibody Status
GBM Reduplication_1
GBM Reduplication_2
Glomerular Capillary Wall C4d Positivity_1
Glomerular Capillary Wall C4d Positivity_2
Glomerulitis (Banff g)_1
Glomerulitis (Banff g)_2
Hepatitis B virus core antibody (HBV cAb) Result
Hepatitis B virus surface antigen (HBV sAg) Result
Interstitial Fibrosis (Banff ci)_1
Interstitial Fibrosis (Banff ci)_2
Interstitial Inflammation (Banff i)_1
Interstitial Inflammation (Banff i)_2
Mesangial C4d Positivity_1
Mesangial C4d Positivity_2
Mesangial Widening (Banff mm)_1
Mesangial Widening (Banff mm)_2
Number of Arteries Affected_1
Number of Arteries Affected_2
Number of Glomeruli_1
Number of Glomeruli_2
Peritubular Capillaritis Inflammation (Banff ptc)_1
Peritubular Capillaritis Inflammation (Banff ptc)_2
Peritubular Capillary C4d Extent_1
Peritubular Capillary C4d Extent_2
Total Interstitial Inflammation (Banff ti)_1
Total Interstitial Inflammation (Banff ti)_2
Tubular Atrophy (Banff ct)_1
Tubular Atrophy (Banff ct)_2
Tubulitis in Non-Atrophic Tubules (Banff t)_1
Tubulitis in Non-Atrophic Tubules (Banff t)_2
Tubulitis of Atrophic Tubules (Banff at)_1
Tubulitis of Atrophic Tubules (Banff at)_2
Vascular Intimal Sclerosis (Banff cv)_1
Vascular Intimal Sclerosis (Banff cv)_2

SDY2944: Regulatory T Cell Modulation in Kidney Transplantation with Biologic Blockade of Dual Effector Pathways, CD28 and IL-6
Status: Updated
Description: A significant problem that continues to challenge transplant physicians is the need to develop immunosuppression strategies that can usher in a tolerant state without the risks associated with conditioning regimens or the threat of graft versus host disease (GVHD) associated with infused stem cells. Other challenges include maintenance of the stability of the tolerant state and the availability of reproducible biomarkers for tolerance. Combining CD28 inhibition with blockade of other co-stimulation tracts or other co-activation pathways has been shown to induce long-term graft acceptance in experimental transplants (Kirk, 1997) (Larsen, 2005) (Zhao, 2012). Co-stimulation inhibition with CTLA4Ig or its second-generation sister drug, belatacept, inhibits T cell activation in vitro and induces anergy but neither agent by itself has been shown to induce tolerance in experimental or clinical organ transplantation (Larsen, 2005) (Kirk, 2014). While tolerance has been demonstrated only in small animals, based on the mechanism of action of IL6 and CTLA4-Ig, their combined inhibition may result in a Treg-mediated tolerogenic environment. CTOT-24 will use a novel therapeutic approach to combine anti-CD28 therapy using lulizumab pegol (BMS-931699) initially, followed by Belatacept, along with inhibition of the IL6 pathway by tocilizumab, an anti-IL6R monoclonal antibody.
Program/Contract:
ProgramContract
Clinical Trials in Organ Transplantation (CTOT) Applying precision MEdicine to optimize desensitization with noveL bIOlogics or cellular theRApies in highly sensiTized kidney transplant patiEnts (AMELIORATE)
DOI: 10.21430/M3LLNPRDY9
Subjects: 15
Study PI, contact:
NameOrganizationSite
Flavio Vincenti UCSF UCSF
Publications:None
Resources:
Assays:None
Clinical Assessments:
Acute Interstitial Nephritis Results_1
Acute Interstitial Nephritis Results_2
Acute T-Cell Mediated Rejection Results_1
Acute T-Cell Mediated Rejection Results_2
Acute Tubular Necrosis Results_1
Acute Tubular Necrosis Results_2
Antibody Mediated Rejection Results_1
Antibody Mediated Rejection Results_2
Bacterial Infection/Pyelonephritis Results_1
Bacterial Infection/Pyelonephritis Results_2
Borderline Changes Results_1
Borderline Changes Results_2
C4d Staining Results_1
C4d Staining Results_2
CNI Toxicity Results_1
CNI Toxicity Results_2
Obstruction/Reflux Results_1
Obstruction/Reflux Results_2
Polyoma/BK Infection Results_1
Polyoma/BK Infection Results_2
Recurrent Disease Results_1
Recurrent Disease Results_2

SDY3079: COBRA N2 NA/NB vaccines and immune response
Status: Updated
Description: A recombinant COBRA N2 NA vaccine was used to elicit immune response in mice following an influenza challenge of SW/NC/15 and Kan/17. Hemagglutination-Inhibition (HAI) and influenza viral plaque assays were conducted using the mice sera samples to detect an increased antibody response that would prove more effective than current seasonal vaccines.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/M3BXRFFJK0
Subjects: 223
Study PI, contact:
NameOrganizationSite
Ted Ross Other: Cleveland Clinic University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Publications:
COBRA N2 NA vaccines induce protective immune responses against influenza viral infection.. Human vaccines & immunotherapeutics Dec 2024. doi: 10.1080/21645515.2024.2403175 [Pubmed: 39291424]
Resources:
Not Applicable Not Applicable]
Assays:
Assay TypeNumber of Exp. Samples
ELISA 160
Hemagglutination Inhibition 104
Other 70
Virus Plaque Assay 56
Clinical Assessments:
Not Applicable

SDY3088: Innate and T-cellular immune responses to sequential vaccination with chimeric hemagglutinin split influenza virus vaccines in mice
Status: Updated
Description: The authors provide an in-depth characterization of the innate immune response and antigen-specific T-cellular immune response in mice.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Sinai-Emory Multi-Institutional CIVIC (SEM CIVIC)
DOI: 10.21430/m3vqfcse7p
Subjects: 112
Study PI, contact:
NameOrganizationSite
Kirill Vasilev Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai, Sinai-Emory Multi-Institutional CIVIC (SEM-CIVIC)
Publications:
None. None None None. doi: None [Pubmed: Not Applicable]
Resources:
Not Applicable Not Applicable]
Assays:
Assay TypeNumber of Exp. Samples
Cytometric Bead Array Assay 80
Flow Cytometry 399
Virus Plaque Assay 96
Clinical Assessments:None

SDY3097: Analysis of SARS-CoV-2 infection and vaccination in high risk participants.
Status: Updated
Description: The study analyzed SARS-CoV-2 vaccination and infections in High Risk participants in the LA-SPARTA cohort. Samples were collected (blood and saliva) and serological responses to the SARS-CoV-2, RBD, and NP were assessed via ELISA assay. Notably, Hispanic participants are at a higher risk of breakthrough infection than non-Hispanic participants among vaccinated individuals.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/m39ybc30zv
Subjects: 200
Study PI, contact:
NameOrganizationSite
Elaine Reed University of California at Los Angeles University of California at Los Angeles, CIVR-HRP
Publications:
Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants.. Frontiers in immunology Apr 2023. doi: 10.3389/fimmu.2023.1139915 [Pubmed: 37153624]
Resources:
Not Applicable https://pubmed.ncbi.nlm.nih.gov/37153624/]
Assays:None
Clinical Assessments:None

SDY3119: Multivalent COBRA influenza vaccine elicits immune response in pre-immune ferrets
Status: Updated
Description: Investigation of the immune response and effectiveness of the next-generation hemagglutinin and neuraminidase proteins, designed using computationally optimized broadly reactive antigen (COBRA) methodology, in elderly ferrets. The animals were pre-immunized with Sing/86 and Pan/99 and prime-boost vaccinated with mixtures of COBRA-based influenza vaccines (J4, Y2, NG2, NG7, NG8, N1-I, and N2-B), and Infectimune adjuvant. The elderly ferrets were challenged with Tas/20; blood samples and nasal washes were collected for several analyses.
Program/Contract:
ProgramContract
CIVICs Collaborative Influenza Vaccine Innovation Centers Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
DOI: 10.21430/m3bra9cso9
Subjects: 36
Study PI, contact:
NameOrganizationSite
Ted Ross Other: Cleveland Clinic University of Georgia, Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP)
Publications:
Multivalent H3 COBRA-based influenza vaccine elicits enhanced immune response in a pre-immune elderly ferret model.. Vaccine May 2025. doi: 10.1016/j.vaccine.2025.127156 [Pubmed: 40267617]
Resources:
Not Applicable Not Applicable]
Assays:None
Clinical Assessments:
Physical Exam