DR18 DataRelease

SDY56: Systems Biology of 2010 trivalent Influenza vaccine (TIV) in young and elderly (see companion study SDY61 2007, SDY270 2009, SDY119 2011)
Status: New
Description: Study Objective
To identify innate signatures that correlate with the magnitude, quality and persistence of B cell responses after vaccination with TIV in the young versus the elderly.

Study Design
Single center, open label study in which adult healthy volunteers with no contraindications to immunization will be vaccinated with TIV. Blood samples will be collected on Days D0 (at enrollment) and D1, D3, D7, D14, D30, D180 post vaccination to study innate and/or adaptive immunity markers. Even though influenza vaccination is considered safe, volunteers will be asked to report any local or systemic AEs from Day 0 (vaccination) to Day 7 in memory aids. Reactogenicity events will also be evaluated by injection site examination on visits at D0, D1, D3 and D7. Volunteers will be also asked to report local and systemic AEs developing the day of a blood draw.
Additionally, only AEs considered related (unlikely, possibly, probably or definitely related) will be collected and reported in this study from Day 0 (vaccination) to Day 180. After Day 30 only related SAEs will be collected and reported.

Study Duration
12 months (6 months accrual and 6 months follow-up period)
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Biological Analysis of Innate and Adaptive Responses to Vaccination
DOI: 10.21430/M3X9SKF8RQ
Subjects: 92
Study PI, contact:
NameOrganizationSite
Bali Pulendran Emory University Emory University
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
Flow Cytometry 745
Hemagglutination Inhibition 364
Luminex xMAP 240
microRNA profiling assay 288
Transcription profiling by array 288
Clinical Assessments:None
SDY87: In-Depth Characterization of Immune Responses to Pneumovax Vaccination in Healthy Subjects
Status: New
Description: This study will measure the immune response to the Pneumovax vaccine The long-term goal is to develop improved vaccines to infectious diseases such as influenza. Blood will be collected from patients at several visits before and after vaccination. The blood will be used in a series of immunological tests to measure the strength and breadth of immune response. These assays may include T cell and B cell activation assays, microarray testing, Epimax, Epigen, and flow cytometry.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3AA0XR32D
Subjects: 5
Study PI, contact:
NameOrganizationSite
A. Karolina Palucka Baylor Research Institute Baylor Research Institute
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
Flow Cytometry 198
Clinical Assessments:
Vitals
SDY89: Systems Biology Analysis of the response to Licensed Hepatitis B Vaccine (Engerix-B) (see companion study SDY690)
Status: New
Description: This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3AYWX8NOT
Subjects: 50
Study PI, contact:
NameOrganizationSite
Robert Coffman Dynavax Technologies Corporation Dynavax Technologies Corporation
Publications:
Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine.. Vaccine. Mar 2012. doi: 10.1016/j.vaccine.2012.02.001. Epub 2012 Feb 14. [Pubmed: 22342916]
Immunogenicity and safety of an investigational hepatitis B vaccine with a Toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared to a licensed hepatitis B vaccine in healthy adults 40-70 years of age.. Vaccine. Nov 2013. doi: 10.1016/j.vaccine.2013.05.068. Epub 2013 May 30. [Pubmed: 23727002]
Immunogenicity of an investigational hepatitis B vaccine with a toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared with a licensed hepatitis B vaccine in subpopulations of healthy adults 18-70 years of age.. Vaccine. Jul 2015. doi: 10.1016/j.vaccine.2015.05.070. Epub 2015 Jun 9. [Pubmed: 26067185]
None. None None None. doi: None [Pubmed: 29289383]
Resources:
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 441
Flow Cytometry 384
Virus Neutralization 147
Clinical Assessments:None
SDY112: T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2011 (See companion studies SDY311 2010 / SDY312 2009 / SDY314 2008 / SDY315 2012)
Status: New
Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M320H8XYFG
Subjects: 93
Study PI, contact:
NameOrganizationSite
Mark Davis Stanford University Stanford University School of Medicine
Publications:None
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT01827462]
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 95
DNA microarray 89
Flow Cytometry 744
Hemagglutination Inhibition 181
Luminex xMAP 352
Clinical Assessments:None
SDY113: Plasmablast response to inactivated and live attenuated influenza vaccines (TIV3/TIV3 ID/LAIV) in 2011
Status: New
Description: To study the plasmablast response to influenza vaccines
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3KPFS7KXI
Subjects: 70
Study PI, contact:
NameOrganizationSite
Harry Greenberg Stanford University Stanford University
Publications:
Distinct cross-reactive B-cell responses to live attenuated and inactivated influenza vaccines.. J Infect Dis. Sep 2014. doi: 10.1093/infdis/jiu190. Epub 2014 Mar 27. [Pubmed: 24676204]
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02141581]
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 61
DNA microarray 57
ELISA 60
ELISPOT 60
Flow Cytometry 358
Hemagglutination Inhibition 128
Luminex xMAP 374
Clinical Assessments:None
SDY278: Optimization FACS panels
Status: New
Description: Optimization of ICS and phenotyping panels for the Mal067 study using cryopreserved PBMC samples from the SAC cohort
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Immune Profile and Network Analysis of Malaria Infection and Vaccination
DOI: 10.21430/M392SKIDA9
Subjects: 1
Study PI, contact:
NameOrganizationSite
Julie McElrath FHCRC FHCRC
Publications:None
Resources:
FHCRC http://www.fhcrc.org/en.html]
Assays:
Assay TypeNumber of Exp. Samples
Flow Cytometry 3
Clinical Assessments:None
SDY289: Live Kidney Donor Study (RELIVE-01)
Status: New
Description: The purpose of this study was to establish a multi-center kidney donor database containing renal failure, cardiovascular and overall mortality information for the complete cohorts of kidney donors who underwent living donor uninephrectomy.
Program/Contract:
ProgramContract
RELIVE CLINICAL OUTCOMES OF LIVE ORGAN DONORS - DATA COORDINATING CENTER
DOI: 10.21430/M3DM0S6FPM
Subjects: 8922
Study PI, contact:
NameOrganizationSite
Sandra Taler Division of Nephrology and Hypertension, Mayo Clinic Mayo Clinic
Publications:
Living donor age and kidney transplant outcomes.. Am J Transplant. Jun 2011. doi: 10.1111/j.1600-6143.2011.03552.x. Epub 2011 May 12. [Pubmed: 21564530]
Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades.. Am J Transplant. Feb 2013. doi: 10.1111/j.1600-6143.2012.04321.x. Epub 2012 Nov 8. [Pubmed: 23137211]
Health-related quality of life in kidney donors from the last five decades: results from the RELIVE study.. Am J Transplant. Nov 2013. doi: 10.1111/ajt.12434. Epub 2013 Sep 6. [Pubmed: 24011252]
Satisfaction With Life Among Living Kidney Donors: A RELIVE Study of Long-Term Donor Outcomes.. Transplantation. Dec 2014. doi: 10.1097/TP.0000000000000360. [Pubmed: 25136843]
Emotional well-being of living kidney donors: findings from the RELIVE Study.. Am J Transplant. Nov 2014. doi: 10.1111/ajt.12906. Epub 2014 Oct 7. [Pubmed: 25293374]
Emotional and Financial Experiences of Kidney Donors over the Past 50 Years: The RELIVE Study.. Clin J Am Soc Nephrol. Dec 2015. doi: 10.2215/CJN.07120714. Epub 2015 Oct 13. [Pubmed: 26463883]
Resources:
Clinicaltrials.gov http://www.clinicaltrials.gov/ct2/show/NCT00608283]
NIH RePORTER http://projectreporter.nih.gov/project_info_details.cfm?aid=7099092&icde=26162432]
Assays:None
Clinical Assessments:None
SDY290: Live Kidney Donor Study - Cross-Sectional and Historical Cohort Study (RELIVE-04)
Status: New
Description: The goal of this study is to determine the long-term risks of donor nephrectomy, compared to appropriate control subjects. This study built on information generated from RELIVE-01, a separate but related retrospective study. Through direct contact with previous living kidney donors this study examined the contribution of living kidney donation to the future development of hypertension, proteinuria, renal insufficiency or renal failure and anemia, the potential through these factors or others for increased cardiovascular risk for clinical events including myocardial infarction (MI), congestive heart failure (CHF), need for coronary artery bypass grafting (CABG) or percutaneous coronary angioplasty (PTCA) revascularization, and the impact of living kidney donation on quality of life (QOL) and financial status, compared to applicable control subjects and populations.
Program/Contract:
ProgramContract
RELIVE CLINICAL OUTCOMES OF LIVE ORGAN DONORS - DATA COORDINATING CENTER
DOI: 10.21430/M39RJDHJVB
Subjects: 196
Study PI, contact:
NameOrganizationSite
Sandra Taler Division of Nephrology and Hypertension, Mayo Clinic Mayo Clinic
Publications:
Living donor age and kidney transplant outcomes.. Am J Transplant. Jun 2011. doi: 10.1111/j.1600-6143.2011.03552.x. Epub 2011 May 12. [Pubmed: 21564530]
Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades.. Am J Transplant. Feb 2013. doi: 10.1111/j.1600-6143.2012.04321.x. Epub 2012 Nov 8. [Pubmed: 23137211]
Health-related quality of life in kidney donors from the last five decades: results from the RELIVE study.. Am J Transplant. Nov 2013. doi: 10.1111/ajt.12434. Epub 2013 Sep 6. [Pubmed: 24011252]
Satisfaction With Life Among Living Kidney Donors: A RELIVE Study of Long-Term Donor Outcomes.. Transplantation. Dec 2014. doi: 10.1097/TP.0000000000000360. [Pubmed: 25136843]
Emotional well-being of living kidney donors: findings from the RELIVE Study.. Am J Transplant. Nov 2014. doi: 10.1111/ajt.12906. Epub 2014 Oct 7. [Pubmed: 25293374]
Emotional and Financial Experiences of Kidney Donors over the Past 50 Years: The RELIVE Study.. Clin J Am Soc Nephrol. Dec 2015. doi: 10.2215/CJN.07120714. Epub 2015 Oct 13. [Pubmed: 26463883]
Resources:
Clinicaltrials.gov http://www.clinicaltrials.gov/ct2/show/study/NCT00951977]
NIH RePORTER http://projectreporter.nih.gov/project_info_details.cfm?aid=7099092&icde=26162432]
Assays:None
Clinical Assessments:None
SDY291: Live Kidney Donor Study -Renal Function Study (RELIVE-06)
Status: New
Description: As part of a cross-sectional study of living kidney donors from 5 to more than 50 years following donor nephrectomy, this study's goal is to accurately measure current Glomerular Filtration Rate (GFR), then to look at the change in GFR from pre to post donation and from early to late time points after donation. This study builds on information generated from RELIVE-01 and RELIVE-04. Through direct contact with previous living kidney donors, this study aims to quantify changes in renal function (measured GFR) from pre to early post donation using data already collected in a related retrospective study (RELIVE 01), and the change in renal function from early (in the first 2 years) post donation to late (beyond the first 2 years) post donation by repeating a GFR measurement. Cross-sectional GFR measurements from black donors compared to white donors matched for age, sex, weight and time from donation will provide data on differences in GFR late after donor nephrectomy by race. When compared to GFR estimates using predictive equations at each of these time points, we can evaluate the accuracy of estimated GFR in white and black donor populations.
Program/Contract:
ProgramContract
RELIVE CLINICAL OUTCOMES OF LIVE ORGAN DONORS - DATA COORDINATING CENTER
DOI: 10.21430/M33MG60QVQ
Subjects: 413
Study PI, contact:
NameOrganizationSite
Sandra Taler Division of Nephrology and Hypertension, Mayo Clinic Mayo Clinic
Publications:
Living donor age and kidney transplant outcomes.. Am J Transplant. Jun 2011. doi: 10.1111/j.1600-6143.2011.03552.x. Epub 2011 May 12. [Pubmed: 21564530]
Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades.. Am J Transplant. Feb 2013. doi: 10.1111/j.1600-6143.2012.04321.x. Epub 2012 Nov 8. [Pubmed: 23137211]
Health-related quality of life in kidney donors from the last five decades: results from the RELIVE study.. Am J Transplant. Nov 2013. doi: 10.1111/ajt.12434. Epub 2013 Sep 6. [Pubmed: 24011252]
Satisfaction With Life Among Living Kidney Donors: A RELIVE Study of Long-Term Donor Outcomes.. Transplantation. Dec 2014. doi: 10.1097/TP.0000000000000360. [Pubmed: 25136843]
Emotional well-being of living kidney donors: findings from the RELIVE Study.. Am J Transplant. Nov 2014. doi: 10.1111/ajt.12906. Epub 2014 Oct 7. [Pubmed: 25293374]
Emotional and Financial Experiences of Kidney Donors over the Past 50 Years: The RELIVE Study.. Clin J Am Soc Nephrol. Dec 2015. doi: 10.2215/CJN.07120714. Epub 2015 Oct 13. [Pubmed: 26463883]
Resources:
Clinicaltrials.gov http://www.clinicaltrials.gov/ct2/show/NCT01158742]
NIH RePORTER http://projectreporter.nih.gov/project_info_details.cfm?aid=7099092&icde=26162432]
Assays:None
Clinical Assessments:None
SDY292: RELIVE Informed Consent Study (RELIVE-03)
Status: New
Description: The goal of this study was to study informed consent by the living donor. This study used surveys to evaluate the understanding of risk and psychological pressure that living organ donors felt when making the decision to donate. It compared participants' answers across geographic, racial and socio-economic backgrounds.
Program/Contract:
ProgramContract
RELIVE CLINICAL OUTCOMES OF LIVE ORGAN DONORS - DATA COORDINATING CENTER
DOI: 10.21430/M3G310ZBSI
Subjects: 636
Study PI, contact:
NameOrganizationSite
Maryam Valapour Cleveland Clinic University of Minnesota
Publications:
Assessing elements of informed consent among living donors.. Clin Transplant. Mar 2011. doi: 10.1111/j.1399-0012.2010.01374.x. [Pubmed: 21158924]
Resources:
Clinicaltrials.gov http://www.clinicaltrials.gov/ct2/show/NCT01742234]
Assays:None
Clinical Assessments:None
SDY294: Live Lung Donor Cross-sectional Cohort Study (RELIVE-05)
Status: New
Description: The Live Lung Donor Cross-sectional Cohort Study (RELIVE-05) aimed to determine the effects of live lung donation on lung function, quality of life, morbidity, psychosocial status, satisfaction with live lung donation, and decision-making associated with live lung donation. This study built on the separate but related RELIVE-02 retrospective study that assessed the effects of live lung donation on survival and short-term morbidity. This multicenter cross-sectional cohort study invited the RELIVE-02 living former live lung donors to undergo questionnaire and pulmonary function test assessments to further determine the long-term outcomes of live lung donation. This study used preoperative donor pulmonary function data and normative data to assist with assessing the effects of live lung donation on lung donors.
Program/Contract:
ProgramContract
RELIVE CLINICAL OUTCOMES OF LIVE ORGAN DONORS - DATA COORDINATING CENTER
DOI: 10.21430/M38LFF1QAA
Subjects: 162
Study PI, contact:
NameOrganizationSite
Mark Barr University of Southern California University of Southern California
Publications:
Morbidity and mortality of live lung donation: results from the RELIVE study.. Am J Transplant. Aug 2014. doi: - [Pubmed: 25039865]
Resources:
Clinicaltrials.gov http://www.clinicaltrials.gov/ct2/show/NCT01524835]
NIH RePORTER http://projectreporter.nih.gov/project_info_details.cfm?aid=7259520&icde=26163672]
Assays:None
Clinical Assessments:None
SDY299: Systems Biology Analysis of the response to Licensed Hepatitis B Vaccine (HEPLISAV) in Whole Blood (see companion studies SDY816 and SDY690)
Status: New
Description: This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M34QI37OT9
Subjects: 25
Study PI, contact:
NameOrganizationSite
Robert Coffman Dynavax Technologies Corporation Dynavax Technologies Corporation
Publications:
Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine.. Vaccine. Mar 2012. doi: 10.1016/j.vaccine.2012.02.001. Epub 2012 Feb 14. [Pubmed: 22342916]
Immunogenicity and safety of an investigational hepatitis B vaccine with a Toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared to a licensed hepatitis B vaccine in healthy adults 40-70 years of age.. Vaccine. Nov 2013. doi: 10.1016/j.vaccine.2013.05.068. Epub 2013 May 30. [Pubmed: 23727002]
Immunogenicity of an investigational hepatitis B vaccine with a toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared with a licensed hepatitis B vaccine in subpopulations of healthy adults 18-70 years of age.. Vaccine. Jul 2015. doi: 10.1016/j.vaccine.2015.05.070. Epub 2015 Jun 9. [Pubmed: 26067185]
None. None None None. doi: None [Pubmed: 29289383]
Resources:
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 225
Nanostring 75
Clinical Assessments:None
SDY300: Healthy Human DC and monocyte subsets transcriptional regulations in response to Fluzone 2010-2011 and pneumococcal vaccinations
Status: New
Description: The described experiments in this study were designed to deconvolute the molecular signature observed in the whole blood of healthy subsets at early time points following the administration of Fluzone 2010-2011 vaccines. RNA-seq data generated from sorted purified cell populations, including mDC and monocyte subsets will permit us to reveal distinct roles that DC and monocyte subsets play in eliciting immune responses to vaccines against flu in healthy adults using system biology approaches.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3FJJ9G9ZZ
Subjects: 10
Study PI, contact:
NameOrganizationSite
A. Karolina Palucka Baylor Research Institute Baylor Research Institute
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
Sequencing 90
Clinical Assessments:None
SDY305: Plasmablast response to inactivated and live attenuated influenza vaccines (TIV3/TIV3 ID) in 2012
Status: New
Description: To study the plasmablast response to 2012 seasonal inactivated influenza vaccine
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3U2R9IV87
Subjects: 25
Study PI, contact:
NameOrganizationSite
Harry Greenberg Stanford University Stanford University
Publications:None
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02141581]
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 23
DNA microarray 24
ELISA 23
ELISPOT 23
Flow Cytometry 296
Hemagglutination Inhibition 48
Luminex xMAP 30
Clinical Assessments:None
SDY311: T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2010 (See companion studies SDY315 2012 / SDY312 2009 / SDY314 2008 / SDY112 2011)
Status: New
Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M33MSDRJ55
Subjects: 76
Study PI, contact:
NameOrganizationSite
Mark Davis Stanford University Stanford-LPCH Vaccine Program
Publications:None
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT01827462]
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 79
DNA microarray 73
Flow Cytometry 464
Hemagglutination Inhibition 140
Luminex xMAP 426
Clinical Assessments:None
SDY312: T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2009 (See companion studies SDY315 2012 / SDY314 2008 / SDY311 2010 / SDY112 2011)
Status: New
Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3G230OYOM
Subjects: 84
Study PI, contact:
NameOrganizationSite
Mark Davis Stanford University Stanford-LPCH Vaccine Program
Publications:
Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans.. Cell Syst. Oct 2016. doi: 10.1016/j.cels.2016.09.009. Epub 2016 Oct 13. [Pubmed: 27746093]
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT01827462]
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 73
Flow Cytometry 1155
Hemagglutination Inhibition 158
Luminex xMAP 484
Clinical Assessments:None
SDY314: T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2008 (See companion studies SDY315 2012 / SDY312 2009 / SDY311 2010 / SDY112 2011)
Status: New
Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3WZ7XK2GG
Subjects: 92
Study PI, contact:
NameOrganizationSite
Mark Davis Stanford University Stanford-LPCH Vaccine Program
Publications:None
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT01827462]
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 91
Flow Cytometry 445
Hemagglutination Inhibition 178
HLA Typing 81
Virus Neutralization 178
Clinical Assessments:None
SDY315: T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination (TIV) - 2012 (See companion studies SDY311 2010 / SDY312 2009 / SDY314 2008 / SDY112 2011)
Status: New
Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3CJT3NCT2
Subjects: 74
Study PI, contact:
NameOrganizationSite
Mark Davis Stanford University Stanford-LPCH Vaccine Program
Publications:None
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT01827462]
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 74
DNA microarray 71
Flow Cytometry 408
Hemagglutination Inhibition 136
Luminex xMAP 138
Clinical Assessments:None
SDY364: Systems Biology Approach to Study Influenza Vaccine 2012-13 in Healthy Children (see companion studies SDY144, SDY368, SDY387)
Status: New
Description: The treatment of pediatric immune system dysfunctions depends upon the basic understanding of its molecular and cellular components, as well as the inherent relationships between these components. Specifically, such knowledge requires an appreciation of B-Iymphocytes, T lymphocytes, natural killer cells and dendritic cells. Research investigating these cells and their functions necessitates the availability and acquisition of peripheral blood samples from healthy children to form control data groups against which various experimental conditions can be measured. Volunteers will be asked to donate blood samples to be used to further study the circulating dendritic cell subpopulations and establish their normal ranges. Blood samples will also be used to isolate antigen specific T lymphocytes, serve as a monocyte source and establish gene signatures.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3U11KLQFF
Subjects: 23
Study PI, contact:
NameOrganizationSite
OCTAVIO RAMILO NATIONWIDE CHILDREN'S HOSPITAL NATIONWIDE CHILDREN'S HOSPITAL
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 79
Flow Cytometry 348
Hemagglutination Inhibition 92
Virus Neutralization 138
Clinical Assessments:
Medical History
Vaccination History
Vital Signs
SDY368: Systems Biology Approach to Study Influenza Vaccine 2013-14 in Healthy Children (see companion studies SDY364, SDY144, SDY387)
Status: New
Description: The treatment of pediatric immune system dysfunctions depends upon the basic understanding of its molecular and cellular components, as well as the inherent relationships between these components. Specifically, such knowledge requires an appreciation of B-Iymphocytes, T lymphocytes, natural killer cells and dendritic cells. Research investigating these cells and their functions necessitates the availability and acquisition of peripheral blood samples from healthy children to form control data groups against which various experimental conditions can be measured. Volunteers will be asked to donate blood samples to be used to further study the circulating dendritic cell subpopulations and establish their normal ranges. Blood samples will also be used to isolate antigen specific T lymphocytes, serve as a monocyte source and establish gene signatures.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3VUYLMJSR
Subjects: 22
Study PI, contact:
NameOrganizationSite
OCTAVIO RAMILO NATIONWIDE CHILDREN'S HOSPITAL NATIONWIDE CHILDREN'S HOSPITAL
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 87
Flow Cytometry 352
Hemagglutination Inhibition 132
Virus Neutralization 132
Clinical Assessments:
Medical History
Vaccination History
Vital Signs
SDY369: Systems Biology Approach to Study Influenza Vaccine in Children with Autoimmunity (Juvenile Dermatomyositis JDM) 2011/2012 Cohort (see companion studies SDY376, SDY372, SDY645)
Status: New
Description: This Project will study vaccine responses in healthy and sick children. It will address the following questions: 1) which are the best biomarkers of protective immune response to influenza vaccine in healthy children; 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner. Ultimately, we expect that these studies will shed light on basic aspects of humoral immune responses to vaccines and will permit us to discover biomarkers of response that can be applied to healthy children and to the general population.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M38SIW861C
Subjects: 4
Study PI, contact:
NameOrganizationSite
Virginia Pascual Baylor Institute for Immunology Research Baylor Institute for Immunology Research
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 12
Flow Cytometry 100
Hemagglutination Inhibition 27
Virus Neutralization 27
Clinical Assessments:
Physical Exam
SDY372: Systems Biology Approach to Study Influenza Vaccine in Children with Autoimmunity (Juvenile Dermatomyositis JDM) 2012/2013 Cohort (see companion studies (SDY369, SDY376, SDY645)
Status: New
Description: This Project will study vaccine responses in healthy and sick children. It will address the following questions: 1) which are the best biomarkers of protective immune response to influenza vaccine in healthy children; 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner. Ultimately, we expect that these studies will shed light on basic aspects of humoral immune responses to vaccines and will permit us to discover biomarkers of response that can be applied to healthy children and to the general population.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3NOD39G06
Subjects: 19
Study PI, contact:
NameOrganizationSite
Virginia Pascual Baylor Institute for Immunology Research Baylor Institute for Immunology Research
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 71
Flow Cytometry 266
Hemagglutination Inhibition 153
Virus Neutralization 153
Clinical Assessments:
Physical Exam
SDY376: Systems Biology Approach to Study Influenza Vaccine in Children with Autoimmunity (Juvenile Dermatomyositis JDM) 2013/2014 Cohort (see companion studies SDY369, SDY372, SDY645)
Status: New
Description: This Project will study vaccine responses in healthy and sick children. It will address the following questions: 1) which are the best biomarkers of protective immune response to influenza vaccine in healthy children; 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner. Ultimately, we expect that these studies will shed light on basic aspects of humoral immune responses to vaccines and will permit us to discover biomarkers of response that can be applied to healthy children and to the general population.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M37IMDD0RO
Subjects: 13
Study PI, contact:
NameOrganizationSite
Virginia Pascual Baylor Institute for Immunology Research Baylor Institute for Immunology Research
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 47
Flow Cytometry 196
Hemagglutination Inhibition 66
Virus Neutralization 66
Clinical Assessments:
Physical Exam
SDY395: Immune Responses to Influenza-Like Illness
Status: New
Description: To investigate the nasal transcriptional response and peripheral plasmablast response in acute influenza infection
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M33RY4IXN7
Subjects: 33
Study PI, contact:
NameOrganizationSite
Harry Greenberg Stanford School of Medicine Stanford School of Medicine
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
Luminex xMAP 62
Clinical Assessments:None
SDY406: Immune Responses to Influenza-Like Illness
Status: New
Description: To investigate the nasal transcriptional response and peripheral plasmablast response in acute influenza infection
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3U4SDFNWN
Subjects: 6
Study PI, contact:
NameOrganizationSite
Harry Greenberg Stanford School of Medicine Stanford School of Medicine
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 4
ELISA 6
Hemagglutination Inhibition 6
Clinical Assessments:None
SDY416: Study to measure the immune response to the influenza vaccine in patients with chronic plaque psoriasis
Status: New
Description: Interleukin-12 (IL-12) and interleukin-23 are heterodimeric cytokines, with a common p40 subunit and a unique chain (IL-12p35 and IL-23p19). The p40 subunit of both interleukins binds to the transmembrane IL-12 receptor-beta1 (IL-12R ) on the surface of T lymphocytes and natural killer cells. Ustekinumab is a fully human monoclonal antibody, anti-IL12p40, which binds to the p40 subunit of IL-12 and IL-23 with high affinity and specificity, inhibiting the activity of both interleukins. Ustekinumab has proven to be highly effective in the treatment of chronic plaque psoriasis, with up to 76% of patients achieving a 75% reduction in their psoriasis area and severity index (PASI-75).1, It is routinely recommended that psoriasis patients treated with biologic therapies such as ustekinumab be vaccinated annually with the influenza vaccine. We can thus assess the importance of these cytokines in the immune response to vaccination by comparing the immune response to influenza vaccination of psoriasis patients treated with ustekinumab with that of patients who are not receiving this treatment. We will assess gene expression profiles and white blood cell subsets in the blood of psoriasis patients before vaccination and at multiple time-points after vaccination.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3KG2XM196
Subjects: 45
Study PI, contact:
NameOrganizationSite
Alan Menter Baylor University Medical Center Baylor University Medical Center
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
ELISA 1064
Flow Cytometry 1036
Clinical Assessments:None
SDY421: Clonal B cell response to naturally occurring pathogens causing tissue specific immune responses in human
Status: New
Description: Elucidate the trafficking specificity, or diversity, of clonal B cell responses to mucosae-associated illnesses or infections in vivo.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3S1P8RAII
Subjects: 4
Study PI, contact:
NameOrganizationSite
Eugene Butcher Stanford University School of Medicine Stanford University School of Medicine
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
Sequencing 11
Clinical Assessments:None
SDY422: DFCI HLA typing
Status: New
Description: We used an in situ synthesized DNA-based microarray method that contains thousands of probes representing a complete overlapping set covering 1,610 clinically relevant HLA class I alleles accompanied by computational tools for assigning HLA type to 4-digit resolution.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Crossprotective CTL Against Influenza
DOI: 10.21430/M354GUQI65
Subjects: 72
Study PI, contact:
NameOrganizationSite
Reinherz Ellis Dana Farber Cancer Institute Dana Farber Cancer Institute
Publications:
Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis.. Front Immunol. Nov 2014. doi: 10.3389/fimmu.2014.00597. eCollection 2014. [Pubmed: 25505899]
Resources:
Assays:
Assay TypeNumber of Exp. Samples
HLA Typing 72
Clinical Assessments:None
SDY460: B and T Cell Determinants of Influenza Vaccine Responses in the Elderly 2008 (see companion study SDY773)
Status: New
Description: Application of high-throughput DNA sequencing of the IGH gene rearrangements to study the B cell repertoires over two successive years in 27 individuals ranging in age from 20 to 89 years old.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M34OUDCFO2
Subjects: 27
Study PI, contact:
NameOrganizationSite
Scott Boyd Stanford University School of Medicine Stanford University School of Medicine
Publications:
Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.. J Immunol. Jan 2014. doi: 10.4049/jimmunol.1301384. Epub 2013 Dec 11. [Pubmed: 24337376]
Resources:
ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01827462]
BioProject http://www.ncbi.nlm.nih.gov/bioproject/PRJNA222239]
Assays:
Assay TypeNumber of Exp. Samples
Sequencing 1296
Clinical Assessments:None
SDY461: Monitoring of tissue-specific immune responses in man to naturally occurring pathogens using mass cytometric monitoring
Status: New
Description: Elucidate the trafficking specificity, or diversity, of clonal B cell responses to mucosae-associated illnesses or infections in vivo.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M31UBL340J
Subjects: 7
Study PI, contact:
NameOrganizationSite
Eugene Butcher Stanford University School of Medicine Stanford University School of Medicine
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 15
Clinical Assessments:None
SDY465: Exploring the human maternal microbiome and its contribution to preterm birth
Status: New
Description: Preterm births occur in 12 percent of pregnancies. Preterm infants are at risk for long term health problems such as impaired hearing and vision, cerebral palsy and developmental delays. This study will characterize the human maternal microbiome and host response profiles associated with term and preterm births and identify features of each that are predicitive of preterm labor and delivery
Program/Contract:
ProgramContract
March of Dimes March of Dimes Human Microbiome
DOI: 10.21430/M3D491LGDT
Subjects: 47
Study PI, contact:
NameOrganizationSite
David Relman March of Dimes Prematurity Research Center at Stanford University School of Medicine March of Dimes Prematurity Research Center at Stanford University School of Medicine
Publications:
Temporal and spatial variation of the human microbiota during pregnancy.. Proc Natl Acad Sci U S A. Sep 2015. doi: 10.1073/pnas.1502875112. Epub 2015 Aug 17. [Pubmed: 26283357]
Resources:
March of Dimes Prematurity Research Center at Stanford University http://prematurity.stanford.edu/]
Stanford University R Markdown http://statweb.stanford.edu/~susan/papers/PNASRR.html.]
Assays:
Assay TypeNumber of Exp. Samples
16S rRNA gene sequencing 4122
Clinical Assessments:
Maternal_Health_and_Pregnancy_Status
SDY472: Plasmablast response to inactivated and live attenuated influenza vaccines (TIV3/TIV3 ID) in 2013
Status: New
Description: This study will be conducted with up to 40 generally healthy children
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3KHTSSSN7
Subjects: 24
Study PI, contact:
NameOrganizationSite
Harry Greenberg Stanford University Stanford University
Publications:None
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02141581]
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 24
Hemagglutination Inhibition 136
Luminex xMAP 46
Clinical Assessments:None
SDY478: T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination - 2013
Status: New
Description: Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3YEJTSS29
Subjects: 70
Study PI, contact:
NameOrganizationSite
Mark Davis Stanford University Stanford-LPCH Vaccine Program
Publications:None
Resources:
clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT01827462]
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 73
Hemagglutination Inhibition 544
Luminex xMAP 138
Clinical Assessments:None
SDY506: CD107 CTL assay
Status: New
Description: CD107A/B assay against influenza infected lung epithelium.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Crossprotective CTL Against Influenza
DOI: 10.21430/M3XV14B6A4
Subjects: 1
Study PI, contact:
NameOrganizationSite
Ellis Reinherz Dana Farber Cancer Institute DFCI
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
Flow Cytometry 15
Clinical Assessments:None
SDY508: Humoral responses to West Nile virus
Status: New
Description: Integrate two high-throughput technologies namely, microengraving-based screening of primary B cells and next-generation sequencing to examine the relationship between the diversity and quality of humoral responses raised and the severity of disease.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Defining signatures for immune responsiveness by functional systems immunology HIPC1
DOI: 10.21430/M3WVUCYBW9
Subjects: 12
Study PI, contact:
NameOrganizationSite
David Hafler Yale Yale
Publications:None
Resources:
NA NA]
Assays:
Assay TypeNumber of Exp. Samples
Sequencing 19
Clinical Assessments:None
SDY517: Natural Killer cells in resistance to infection with West Nile virus
Status: New
Description: Examine the response of primary NK cells from subjects with a history of asymptomatic or severe infection with West nile virus
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Defining signatures for immune responsiveness by functional systems immunology HIPC1
DOI: 10.21430/M3NI5JARF2
Subjects: 14
Study PI, contact:
NameOrganizationSite
David Hafler Yale Yale
Publications:None
Resources:
NA NA]
Assays:
Assay TypeNumber of Exp. Samples
CyTOF 56
Clinical Assessments:None
SDY520: Immunologic and genomic signatures of influenza vaccine response - 2013 (see companion studies SDY63, SDY404, SDY400)
Status: New
Description: Project 1: Immunologic and genomic signatures of influenza vaccine response - year4 2013
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Defining signatures for immune responsiveness by functional systems immunology HIPC1
DOI: 10.21430/M3KVVHM735
Subjects: 61
Study PI, contact:
NameOrganizationSite
David Hafler Yale Yale
Publications:None
Resources:
NA NA]
Assays:
Assay TypeNumber of Exp. Samples
Hemagglutination Inhibition 114
Transcription profiling by array 99
Clinical Assessments:None
SDY523: Peptide display hierarchy protocol
Status: New
Description: Peptide display hierarchy
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Crossprotective CTL Against Influenza
DOI: 10.21430/M3UJNPPHFY
Subjects: 1
Study PI, contact:
NameOrganizationSite
Ellis Reinherz Harvard Medical School Dana Farber Cancer Institute
Publications:None
Resources:
Reinherz Lab http://dms.hms.harvard.edu/immunology/fac/Reinherz.php]
Assays:
Assay TypeNumber of Exp. Samples
Mass Spectrometry 20
Clinical Assessments:None
SDY597: DC transcriptomics in response to vaccines
Status: New
Description: The mechanisms by which microbial vaccines interact with human APCs remain elusive.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3AC1WMBDO
Subjects: 20
Study PI, contact:
NameOrganizationSite
Romain Banchereau Baylor Institute for Immunology Research Baylor Institute for Immunology Research
Publications:
Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines.. Nat Commun. Oct 2014. doi: 10.1038/ncomms6283. [Pubmed: 25335753]
Resources:
NA NA]
DC Modules http://dcmodules.com/users/sign_in]
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 413
Clinical Assessments:None
SDY640: Immunologic and genomic signatures of influenza vaccine response - 2014
Status: New
Description: Project 1: Immunologic and genomic signatures of influenza vaccine response - year5 2014
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Defining signatures for immune responsiveness by functional systems immunology HIPC1
DOI: 10.21430/M3A6GYD5L0
Subjects: 37
Study PI, contact:
NameOrganizationSite
David Hafler Yale Yale
Publications:None
Resources:
LN1 NA]
Assays:
Assay TypeNumber of Exp. Samples
Hemagglutination Inhibition 280
Clinical Assessments:None
SDY645: Systems Biology Approach to Study Influenza Vaccine in Children with Autoimmunity (Juvenile Dermatomyositis JDM) 2014/2015 Cohort (see companion studies SDY369, SDY376, SDY372)
Status: New
Description: This Project will study vaccine responses in healthy and sick children. It will address the following questions: 1) which are the best biomarkers of protective immune response to influenza vaccine in healthy children; 2) how unique autoimmune backgrounds set the stage for responsiveness/unresponsiveness to vaccines; 3) whether vaccination contributes to increase the breadth of autoimmunity in a disease-specific manner. Ultimately, we expect that these studies will shed light on basic aspects of humoral immune responses to vaccines and will permit us to discover biomarkers of response that can be applied to healthy children and to the general population.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M35HMSDTHH
Subjects: 11
Study PI, contact:
NameOrganizationSite
Virginia Pascual Baylor Institute for Immunology Research Baylor Institute for Immunology Research
Publications:None
Resources:
N/A N/A]
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 39
Flow Cytometry 160
Hemagglutination Inhibition 464
Virus Neutralization 464
Clinical Assessments:None
SDY667: The immune signature of palmoplantar pustulosis
Status: New
Description: This study will compare adult patients with CPP(chronic plaque type psoriasis ), who are currently not undergoing topical, systemic or biologic treatment and matched healthy controls. Baseline demographics and psoriasis history will be recorded. All PPP patients will be comprehensively phenotyped and psoriasis severity assessed including the body surface area (BSA) involved, Psoriasis Area and Severity Index (PASI), Physicians Global assessment (PGA) and Dermatology Life Quality Index (DLQI).
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M34NBAVDGJ
Subjects: 50
Study PI, contact:
NameOrganizationSite
Gerlinde Obermoser Baylor Institute for Immunology research Baylor Institute for Immunology research
Publications:None
Resources:
N/A N/A]
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 138
Clinical Assessments:None
SDY675: Heritable influence on the B and T cell receptor repertoire
Status: New
Description: The adaptive immune systems capability to protect the body requires a highly diverse lymphocyte antigen receptor repertoire. However, the influence of individual genetic and epigenetic differences on these repertoires is frequently underestimated. By leveraging the unique characteristics of B, CD4+ T, and CD8+ T lymphocyte subsets isolated from monozygotic twins, we have elucidated the impact of heritable factors on the V(D)J recombination process and have shown that the repertoires of both naive and antigen experienced cells are subject to biases resulting from initial recombination differences. Moreover, we show that the relative usage of V and J gene segments is chromosomally biased, with approximately 1.5 times as many rearrangements originating from a single chromosome. These data refine our understanding of the heritable mechanisms affecting the repertoire, and show that bias exists on a chromosome-wide level.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M3XMYVQI9X
Subjects: 10
Study PI, contact:
NameOrganizationSite
Mark M Davis Stanford University Stanford University
Publications:
Individual heritable differences result in unique cell lymphocyte receptor repertoires of naive and antigen-experienced cells.. Nat Commun. Mar 2016. doi: 10.1038/ncomms11112. [Pubmed: 27005435]
Resources:
NCBI BIOPROJECT http://www.ncbi.nlm.nih.gov/bioproject/PRJNA300878]
VDJ Server Homo sapiens B and T cell repertoire - MZ twins https://vdjserver.org/community/531076969703215591-242ac11c-0001-012/metadata]
Assays:
Assay TypeNumber of Exp. Samples
Sequencing 10
Clinical Assessments:None
SDY690: Systems Biology Study to Investigate Immune Correlates to Hepatitis B Vaccine Engerix-B comparing cellular responses and gene expression patterns between PBMCs (cell sorts) and whole blood samples (see companion studies SDY816 and SDY299)
Status: New
Description: This project will contribute to the overall vision and goals of this U19 by analyzing the role of adjuvants in the humoral response to hep B vaccination in healthy individuals.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
DOI: 10.21430/M3F8W7VA7O
Subjects: 12
Study PI, contact:
NameOrganizationSite
Robert Coffman Dynavax Technologies Corporation Dynavax Technologies Corporation
Publications:
Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine.. Vaccine. Mar 2012. doi: 10.1016/j.vaccine.2012.02.001. Epub 2012 Feb 14. [Pubmed: 22342916]
Immunogenicity and safety of an investigational hepatitis B vaccine with a Toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared to a licensed hepatitis B vaccine in healthy adults 40-70 years of age.. Vaccine. Nov 2013. doi: 10.1016/j.vaccine.2013.05.068. Epub 2013 May 30. [Pubmed: 23727002]
Immunogenicity of an investigational hepatitis B vaccine with a toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared with a licensed hepatitis B vaccine in subpopulations of healthy adults 18-70 years of age.. Vaccine. Jul 2015. doi: 10.1016/j.vaccine.2015.05.070. Epub 2015 Jun 9. [Pubmed: 26067185]
None. None None None. doi: None [Pubmed: 29289383]
Resources:
NA NA]
Assays:
Assay TypeNumber of Exp. Samples
DNA microarray 192
Clinical Assessments:None
SDY702: Human T Cell Profile
Status: New
Description: We present a quantitative, system-wide analysis of T cell differentiation, homeostasis and persistence in blood, lymphoid, and mucosal tissues obtained from a highly diverse cohort of 56 organ donors aged 3?73 years. We incorporate an analysis of naive, memory, and effector T cells with functional markers of homeostasis, activation, and tissue residence along with quantification of in situ turnover and TCR clonal distribution to reveal distinct patterns of compartmentalization, maintenance and proliferation of human T cells.
Program/Contract:
ProgramContract
Tissue compartmentalization of human lymphocytes P01AI106697 Tissue compartmentalization of human lymphocytes
DOI: 10.21430/M39EBHNRYF
Subjects: 56
Study PI, contact:
NameOrganizationSite
Donna Farber Columbia University CCTI
Publications:
Spatial map of human T cell compartmentalization and maintenance over decades of life.. Cell. Nov 2014. doi: 10.1016/j.cell.2014.10.026. [Pubmed: 25417158]
Resources:
Assays:
Assay TypeNumber of Exp. Samples
Flow Cytometry 301
Clinical Assessments:None
SDY753: Investigating Alterations to the Nasal Microbiome after Vaccination with LAIV
Status: New
Description: The goal of this proposal is to characterize alterations to the nasal microbiome after vaccination with the 2012-2013 seasonal LAIV and to correlate these changes with LAIV-specific immune responses (A/California/7/2009 (H1N1) and A/Victoria/361/2011 (H3N2)).
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune Profiling
DOI: 10.21430/M3ENN2D3SZ
Subjects: 47
Study PI, contact:
NameOrganizationSite
Gregory Poland Mayo Clinic Mayo Clinic
Publications:None
Resources:
Assays:
Assay TypeNumber of Exp. Samples
ELISA 94
Sequencing 121
Clinical Assessments:None
SDY756: Histology post influenza
Status: New
Description: Histological analysis in lung post infection of B6 or B6 A02 transgenic AAD mice with influenza A/PR8/34 virus
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Crossprotective CTL Against Influenza
DOI: 10.21430/M3EWWO0ERE
Subjects: 1
Study PI, contact:
NameOrganizationSite
Ellis Reinherz Harvard Medical School Dana Farber Cancer Institute
Publications:None
Resources:
Reinherz Lab http://dms.hms.harvard.edu/immunology/fac/Reinherz.php]
Assays:
Assay TypeNumber of Exp. Samples
Microscopy 20
Clinical Assessments:None
SDY773: B and T Cell Determinants of Influenza Vaccine Responses in the Elderly 2009 (see companion study SDY460)
Status: New
Description: Application of high-throughput DNA sequencing of the IGH gene rearrangements to study the B cell repertoires over two successive years in 27 individuals ranging in age from 20 to 89 years old.
Program/Contract:
ProgramContract
Human Immunology Project Consortium 1 (HIPC1) Vaccination and infection: indicators of immunological health and responsiveness
DOI: 10.21430/M35OPGLUTH
Subjects: 27
Study PI, contact:
NameOrganizationSite
Scott Boyd Stanford University School of Medicine Stanford University School of Medicine
Publications:
Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.. J Immunol. Jan 2014. doi: 10.4049/jimmunol.1301384. Epub 2013 Dec 11. [Pubmed: 24337376]
Resources:
ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01827462]
BioProject http://www.ncbi.nlm.nih.gov/bioproject/PRJNA222239]
Assays:
Assay TypeNumber of Exp. Samples
Sequencing 1296
Clinical Assessments:None
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